Chronic hepatitis B virus (HBV) infection, which ultimately leads to liver cirrhosis, hepatic decompensation, and hepatocellular carcinoma (HCC), remains a significant disease burden worldwide.Despite the use of antiviral therapy (AVT) using oral nucleos(t)ide analogs (NUCs) with high genetic barriers, the risk of HCC development cannot be complete
Pipe routing and clamp layout for aeroengine are NP-hard computational problems and complex engineering design processes.Besides space constraints and engineering rules, there are assembly constraints between pipes and clamps, which usually lead to repeatedly modifications between pipe routing and clamp layout designs.In order to solve the problems
Dairy products such as raw milk and artisanal cheeses are marketed in open markets and directly at home throughout Brazil, even with prohibitions in Brazilian legislation, leading in many cases to the production of food without hygienic conditions that can be configured as an important source transmission of pathogens and, consequently, a danger to
Many adolescents living with or without HIV are sexually active and in need of continuous free access to a variety of contraceptive methods.Dual contraception, condom use together with reversible effective contraception (hormonal contraception [HC] Lighting or intrauterine device), seems to be the most effective option for female adolescents for pr